Susceptibility of swine cells and domestic pigs to SARS-CoV-2
David A. Meekins,a Igor Morozova, Jessie D. Trujilloa, Natasha N.
Gaudreaulta, Dashzeveg Bolda, Bianca L. Artiagaa, Sabarish V. Indrana,
Taeyong Kwona, Velmurugan Balaramana, Daniel W. Maddena, Heinz
Feldmannb, Jamie Henningsona, Wenjun Maa,c, Udeni B. R. Balasuriyad,
and Juergen A. Rich
David A. Meekins,a Igor Morozova, Jessie D. Trujilloa, Natasha N.
Gaudreaulta, Dashzeveg Bolda, Bianca L. Artiagaa, Sabarish V. Indrana,
Taeyong Kwona, Velmurugan Balaramana, Daniel W. Maddena, Heinz
Feldmannb, Jamie Henningsona, Wenjun Maa,c, Udeni B. R. Balasuriyad,
and Juergen A. Rich
"In the current study, we determined the ability of SARS-CoV-2 to (i) replicate in porcine cell lines, (ii) establish infection in domestic pigs via experimental oral/intranasal/intratracheal inoculation, and (iii) transmit to co-housed naive sentinel pigs. SARS-CoV-2 was able to replicate in two different porcine cell lines with cytopathic effects."
But they conclude: "Pigs are therefore unlikely to be significant carriers of SARS-CoV-2 and are not a suitable pre-clinical animal model to study SARS-CoV-2 pathogenesis or efficacy of respective vaccines or therapeutic."
Is this study trustworthy? Do we need a second opinion?
