Porcine Coronavirus University: Pork, Pigs, Pigeons, and COVID-19

Please call your Congressional Representatives and urge them to demand that the USDA begin screening pigs for the Covid-19 virus.

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If COVID-19 is a coinfection of African Swine Fever, what role can Chloroquine play?

Effect of Chloroquine on African Swine Fever Virus Infection

A. Geraldes and M. L. Valdeira
First Published: 01 May 1985 Effect of Chloroquine on African Swine Fever Virus Infection | Microbiology Society

Effect of Chloroquine on African Swine Fever Virus Infection | Microbiol...

A. Geraldes|M. L. Valdeira

Summary When present during the whole infective cycle, the lysosomotropic drug, chloroquine, inhibited cytopathi...

https://www.microbiologyresearch.org/docserver/fulltext/jgv/66/5/JV0660051145.pdf?expires=1584641775&id=id&accname=guest&checksum=2B179ACEFF5CF7991065F2DA8FBCF8AE

on March 19, 2020

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Microbiologist Florian Krammer suggests pigs might be the intermediate vectors of COVID-19

The final host here is humans. So the 'intermediary host' (if there was one) cannot be a human. Instead of looking for far fetched...
The ACE2 receptors in pigs might indicate that pigs are a big issue for COVID-19 (the Wuhan Coronavirus)

ACE2 receptors have been shown to be the entry point into human cells for some coronaviruses, including the SARS virus . A number of studie...
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Microbiologist Florian Krammer suggests pigs might be the intermediate vectors of the Wuhan Coronavirus The final host here is humans. ...
Did Covid-19 come from pork? Xinfadi houses 5,000 wholesalers trading 14m tons of meat, fruit and vegetables each year.

http://www.fruitnet.com/asiafruit/article/166108/beijing-downsizes-xinfadi-wholesale-market
Yes, it looks like pigs may be involved with the COVID-19 pandemic or soon will be.

I find this super interesting: https://t.co/IuhToP2WZZ Dogs? Cats? Pigs? Susceptible? There was replication in a dog reported.... — Flori...
Is China's pork infected with the Covid-19 virus?

Covid-19 outbreak near Beijing's biggest meat market https://www.washingtonpost.com/world/beijing-goes-into-wartime-mode-as-virus-emerg...

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An Ontario Veterinarian warns that COVID-19 could infect pigs

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Mother Jones: As for SARS-CoV-2, the coronavirus causing the current COVID-19 pandemic, a study released in June by Chinese researchers found that pigs are at least theoretically susceptible: They have lung and kidney cells that can be invaded by this particular pathogen. But laboratory attempts to infect pigs with it have so far not succeeded. “Given that the COVID-19 pandemic is still progressing and SARS-CoV-2 strains are constantly evolving,” they wrote, “we need to keep monitoring and evaluating the possibility of pigs to become intermediate hosts” of the pathogen. Gray finds the prospect of hog-adapted SARS-CoV-2 daunting. As they do for flu, pigs could emerge as what disease researchers call a “reservoir” for the pathogen—a large host population that keeps the pathogen circulating, giving it more opportunity to infect people. “My chief concern is that the current SARS-CoV-2 virus adapts to commercial hogs, becomes amplified in them, and causes widespread infections, increasing the risk of the virus moving from the pigs to infect humans who have not been previously infected,” he said. He expressed an even darker possibility: The “remote chance” that if it does manage to enter the pig population, it could mutate into something different, yet another “novel coronavirus” that would require a whole new scramble for a vaccine.

Source: Tom Philpott in Mother Jones https://www.motherjones.com/food/2020/08/industrial-hog-farms-are-breeding-the-next-pandemic/
Are pigeons in NYC infected with COVID-19? There are 7 million pigeons in New York City. They have ACE2 receptors that could be susceptible to COVID-19.

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An Ontario Veterinarian warns that COVID-19 could infect pigs

"There’s also an animal side here, in the vein of what I’ve been talking about for a while. This study predicts that the COVID-19 virus...
Mother Jones: As for SARS-CoV-2, the coronavirus causing the current COVID-19 pandemic, a study released in June by Chinese researchers found that pigs are at least theoretically susceptible: They have lung and kidney cells that can be invaded by this particular pathogen. But laboratory attempts to infect pigs with it have so far not succeeded. “Given that the COVID-19 pandemic is still progressing and SARS-CoV-2 strains are constantly evolving,” they wrote, “we need to keep monitoring and evaluating the possibility of pigs to become intermediate hosts” of the pathogen. Gray finds the prospect of hog-adapted SARS-CoV-2 daunting. As they do for flu, pigs could emerge as what disease researchers call a “reservoir” for the pathogen—a large host population that keeps the pathogen circulating, giving it more opportunity to infect people. “My chief concern is that the current SARS-CoV-2 virus adapts to commercial hogs, becomes amplified in them, and causes widespread infections, increasing the risk of the virus moving from the pigs to infect humans who have not been previously infected,” he said. He expressed an even darker possibility: The “remote chance” that if it does manage to enter the pig population, it could mutate into something different, yet another “novel coronavirus” that would require a whole new scramble for a vaccine.

Source: Tom Philpott in Mother Jones https://www.motherjones.com/food/2020/08/industrial-hog-farms-are-breeding-the-next-pandemic/
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Do the commonalities of SARS-CoV and SARS-CoV-2 increase the probability that pigs are involved with COVID-19?

SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor https://marlin-prod.literatumon...
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Is hypoxia a clue that African Swine Fever may be involved with COVID-19?

One of the first people to be affected with COVID-19 in Wuhan sold pork at the Wuhan seafood market. Were they also infected with Africa...
Researchers in China may have issued warning about Covid-19 in pork: "Besides pets, livestock are another category of mammals that are frequently in direct contact with humans. We profiled the ACE2 expression in cows, pigs, rabbits (which can also serve as pets), and goats. In these animals, ACE2 was highly expressed in multiple tissues including kidney, liver, and heart, but not in muscles (Figures 5D-5F and S2B in Supplementary data). ACE2 was also highly expressed in the fat of pigs. The data suggested that storage of fresh or undercooked meat, especially viscera tissues, might be risky."

Source: Atlas of ACE2 gene expression in mammals reveals novel insights in transmisson of SARS-Cov-2 Kun Sun1,*, Liuqi Gu2, Li Ma1, Yunfeng...

Read an excerpt of a novel about a pig disease that could cause a human pandemic.

The African Swine Fever Novel by rubiconmedia on Scribd

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Microbiologist Florian Krammer suggests pigs might be the intermediate vectors of COVID-19

The final host here is humans. So the 'intermediary host' (if there was one) cannot be a human. Instead of looking for far fetched...

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